THE 2-MINUTE RULE FOR BET ON SPORTS

DNA ligases seal five′-PO4 and three′-OH polynucleotide finishes by using 3 nucleotidyl transfer actions involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are essential guardians of genomic integrity, and ligase dysfunction underlies human genetic sickness syndromes. Crystal structures of DNA ligases certain to nucleotide